Ideological and political education at university is crucial for the great mission of cultivating builders and successors of socialism with Chinese characteristics. In the new era, ideological and political work at universities should set off from the new trend of global development, domestic development and college students' study and campus life. And how to carry out sound ideological and political work should be base on the four new pathways——enriching new contents, innovating new forms, constructing new topics and reshaping new the image of ideological and political education practitioners.