At present, the construction of an innovation and entrepreneurship education system based on the cultivation of new engineering talents is an important task for the reform and development of college education. This article takes the mechanical manufacturing and automation specialty (mechanism) as an example to analyze the characteristics of the era of innovation and entrepreneurship education in the context of new engineering, the problems of college innovation and entrepreneurship education, proposes the construction and implementation strategies of mechanical design and manufacturing and its automation (mechanism) innovation and entrepreneurship education system, and thus provides guarantee for the development of mechanism majors in our school and the cultivation of new engineering talents.