There are major problems of higher vocational school we consider from epistemology,which include lack of necessary judgement and choice in knowledge among teachers,lack of joint construction in knowledge among teachers and students,lack of deep consideration of epistemology in curriculum construction,lack the guidance of epistemology in teaching evaluation,and lack of guidance of epistemology to teachers and students. There are major characteristics of higher vocational school we consider from attribute of knowledge,which include the fitness of higher vocational school teaching content is determined by selectivity of knowledge,responsibility of higher vocational school teaching process is determined by integrality of knowledge,and validity of learning is determined by transferability and controllablity of knowledge. There are major strategies of higher vocational school teaching,which include to judge and choose the value of higher vocational school teaching knowledge form classification of knowledge,to promot students development from the angle of comprehension of knowledge,to form rational curriculum structure of higher vocational school from structure of knowledge system,and to guide teachers and students from the angle of learning of epistemology.