Based on ecological education and outcome based education (OBE), we integrate the advantages of KAB and SIYB entrepreneurship courses, combined with our own innovation and entrepreneurship education practice, put forward a "Trinity" KGSIE course system for university innovation and entrepreneurship education. The main features, the construction train of thought, the basic content and the problems in the build process of the system are also elaborated. It has important theoretical and practical significance for improving the concept of innovation and entrepreneurship education, the quality and effect of teaching, and the overall quality of talent training and school education.