According to the data from the Ministry of Education, the total number of college graduates in 2021 is 9.09 million, a year-on-year increase of 350,000. The rapid increase in the number of graduates has led to a more prominent “difficult employment” problem. As a special group, college graduatesare faced with many uncertainties in employment. These employment uncertainties can easily lead to anxiety, depression and other unhealthy emotions among college graduates. Therefore, individualized intervention on the main influencing factors is of great significance to solve their employment psychological problems and promote psychological and physical health. This paper analyzes the psychological factors affecting the employment of college graduates, proposes targeted intervention measures, evaluates their effects, and provides more references for improving the physical and mental health of college graduates.