The Communist Party of China has nurtured the red gene with the red spirit as the core in the great practice of revolution, construction and reform. As a high fusion of the red spirit, the red gene is a vivid embodiment and manifestation of the Party's nature and purpose, ideals and beliefs, spiritual style, and the excellent traditional culture of the Chinese nation in different historical periods. In the course of the Party's 100-year history, the red gene has revealed the distinctive characteristics of historicity, advancement and stability. Standing at the historical intersection of the two centuries, it is necessary to systematically elaborate and fully explore the scientific connotation of the red gene on the basis of its important role in strengthening the Party's construction, deepening reform and opening up and cultivating new generations in the new era. The inheritance of the red gene in the new era presents the characteristics of the path from carrier development to connotation excavation, from regional inheritance to overall linkage, from top-level design to grassroots innovation.