From the perspective of blended teaching, colleges and universities can effectively cultivate students' autonomous learning ability on the basis of respecting the dominant position of students and showing the concept of people-oriented teaching, and then drive curriculum teaching to achieve the goal of innovative changes. However, in the current environment, colleges and universities are still facing obstacles such as traditional teachers' ideas, lack of students' enthusiasm, unreasonable online and offline teaching settings, and backward teaching evaluation systems, which seriously affect the improvement of students' autonomous learning ability. To this end, colleges and universities should update teachers' teaching concepts, improve teachers' comprehensive quality, cultivate students' interest in participating in blended teaching, and scientifically arrange online and offline teaching in blended teaching and the integration of the two sides to ensure the effective implementation of blended teaching. At the same time, colleges and universities are supposed to focus on the innovation of the blended teaching evaluation system, and fully examine the cultivation effect of students' autonomous learning ability from the perspective of blended teaching, so as to provide assistance for improving students' autonomous learning ability.