Based on the panel data of 26 cities in the urban agglomeration of Yangtze River Delta from 2010 to 2020, taking into account the development status of urban resilience and livability, this paper uses the entropy method to calculate the comprehensive development index of resilience and livability in question, on the basis of which the coupling coordination model is further used for quantitative analysis. The results show that the overall level of urban resilience and livability in the Yangtze River Delta is rising, and the development level of urban livability is slightly higher than that of urban resilience; the coupling coordination index of the two systems is relatively high, and the overall situation is relatively stable. The coupling coordination degree of Shanghai within the region remains at the highest level, and the coordination city types are mainly primary and intermediate coordination; in the spatial pattern, the coupled and coordinated urban plate shows a round-type gathering distribution. Accordingly, the paper puts forward policy suggestions such as strengthening the resilience construction to improve the city’s ability to resist risks, building a livable and resilient city with characteristic development according to local conditions, and realizing the coordinated development of the urban agglomeration of Yangtze River Delta through urban transformation, so as to enhance its overall comprehensive development capacity and have a radiation influence on the whole urban agglomeration.