Under the background of the new era, higher requirements are put forward for the cultivation of innovative and entrepreneurial talents. Taking the school-enterprise deep cooperation between Hebei University of Engineering and Chenguang Biotechnology Group Co., Ltd as an example, on the basis of the in-depth integration of the university and enterprise based on the sharing of talents, platform construction and resource sharing, the "Chenguang Cup" College students' Innovation and creativity Competition as the carrier, and the research on the curriculum system of the school's innovation and entrepreneurship education as the left. Based on the construction of public practice and training bases for innovation and entrepreneurship in enterprises, a training mode for innovation and entrepreneurship talents with "Five double" as the core is explored, aiming to provide theoretical and practical reference for training new talents for innovation and entrepreneurship.