Integration of specialty and innovation conforms to the new trend of the reform and development of higher education, and constructive alignment helps to improve teaching quality. This paper, taking the course Building Architecture as an example, analyzes its traditional teaching problems; based on "integration of specialty and innovation+constructive alignment", this paper explains that teaching with high alignment is organized in the perspectives of preset learning outcomes, process and evaluation, along with innovation and entrepreneurship education. Based on students’ learning situation, this study firstly classifies the learning points of the course by using Bloom’s Taxonomy of educational objectives, then implements teaching with mixture of online & offline teaching, project-based teaching and case teaching, and analyzes the students’ achievements and questionnaire feedback, finally offering improved suggestions. The result shows that this innovative mode could improve students’ learning effects, and gives them better learning experiences. The practice on "integration of specialty and innovation+constructive alignment" could provide certain reference values for university curriculum reforms.