To solve the problems in the cultivation of compound applied talents, Hebei University of Engineering sticks to morality education and implements OBE principles. Further, it constructs and practices the "one-three-fourteen" talent cultivation system driven by professional accreditation and empowered by the integration of industry and education. Based on the demands of industry development and the conception of outcome orientation, Hebei University of Engineering has cultivated many compound applied talents to serve the development of industries and local economy. To achieve this, the university has built a principal teaching model, put simply, the combination of discipline and specialty, curriculum system, classroom teaching, practical training, and cooperation with industries. Meanwhile, the university takes faculty development and resource construction as its fundamentals; it also focuses on the integration of teaching and students’ contests, educating students in five domains simultaneously as well as the ability of innovation and entrepreneurship among students. Besides, the university highlights the co-effect of management system, quality monitoring system, evaluation and feedback mechanism, and quality-oriented culture. It has been demonstrated that the reformed talent cultivation system is much more reasonable than the previous one. Accordingly, the quality of talent cultivation has been improved steadily. Likewise, the five criteria in this talent cultivation system, namely, the degree of adaptability, guarantee, satisfaction, validity, and goal achievement, have been optimized continuously. In this sense, this paper provides some colleges and universities with suggestions on the high-quality connotative development and comprehensive quality improvement of talent cultivation.