The triple helix theory is the basic theory of cooperative innovation in modern industry colleges, which defines the roles of universities, government and enterprises in the process of running schools. Based on this theory, this paper constructs a "3-3-4-5" collaborative innovation model, in which triple helix of governments, universities and enterprises is established, three types of integration are achieved, namely the integration between industry and education, university and local government as well as science and innovation. Also in this model, four chains are connected, namely, the education chain, the talent chain, the industry chain, and the innovation chain. Besides, five important factors are linked in this model, that is, the enterprise, the industrial field, the industry, the occupation, and the specialty. Accordingly, based on the concept of co-construction of carriers, co-cultivation of talents and sharing of achievements, this paper takes College of Cross-Border E-Commerce Industry of Hebei University of Geosciences as an example and analyzes the ideas of cooperative innovation of modern industry colleges from the perspectives of organization construction, operation mode, education mode, management system and entrepreneurship education. In this sense, this paper is not only an evolution and deepening of triple helix theory and cooperative innovation paradigm, but also an exploration of the construction of modern industrial colleges.