The main reason for the proposal of the new engineering department is that the engineering talents cultivated by China’s traditional engineering education are not suitable for the new needs of the current social and economic development. There is an urgent need to cultivate new engineering talents through the transformation and upgrading of engineering education. It provides support for China’s transformation from a big country in engineering education to a strong country in engineering education. To this end, this paper proposes a new engineering microcontroller principle and application curriculum reform plan based on the curriculum chain. By coordinating the training objectives of the front-end and back-end of the course chain, we design a training program that is more in line with the requirements of social enterprises. We have clarified the teaching content and teaching methods of innovative courses, increased multi-dimensional practical training, strengthened school-enterprise cooperation, and promoted the formation of innovative collaborative training models. These measures promote the innovation, reform and development of curriculum teaching. It adapts to the development ideas and overall goals of emerging engineering education.