Mechanics of materials is an important basic technical course for most engineering majors. With the deepening of education and teaching reform in colleges and universities, the teaching hours of basic technical course have been reduced, but the requirements of college students’ engineering practice ability have been gradually increased. Mechanics of materials is a relatively theoretical and abstract course, and the students’ knowledge reserve in the early stage varies a lot. Therefore, it is difficult to balance the sutdy of theoretical knowledge and the needs of society and the industry in the limited credit hours; in this sense, it is more difficult to strengthen students’ engineering practical ability and achieve good teaching effect, which is mainly based on the certification standards of engineering education and the education orientation and the talent cultivation goal of the university. Accordingly, this paper firstly reconstructs and designs the teaching content of material mechanics, and then implements the teaching of the applied material mechanics from four aspects; that is, the organic integration of ideological and political elements into the curriculum, adopting a blended online and offline teaching approach, the dual integration of case studies and disciplinary contest resources into teaching, and the optimization of examination and assessment methods. The analysis of teaching achievements shows that the students’learning enthusiasm and initiatives as well as their mastery of theoretical knowledge and abilty to solve complex engineering problems have been significantly improved. In this sense, this teaching reform, with a good teaching effect, has achieved the goal of cultivating talents.