In recent years, the rise of digital business forms has injected vitality into the deep integration of live streaming e-commerce and physical enterprises. Based on the perspective of customer stickiness, the spatial sense of presence is integrated on the basis of the social sense of presence, the structural equation model is constructed, and the questionnaire survey method is used to empirically explore the influence mechanism of consumers’ continuous purchase intention in live streaming e-commerce. It is found that the three characteristics of anchor information source positively influence the customers’ social sense of presence; social sense of presence has an extremely positive impact on customer stickiness and a significant positive influence on customers’ continuous purchase intention. It is also observed that high-level and low-level spatial sense of presence play a significant and an extremely significant positive moderating role respectively between customer stickiness and continuous purchase intention. Simultaneously, customer stickiness plays an extremely significant mediating role between social sense of presence and continuous purchase intention. Accordingly this paper puts forward that enterprises should carefully cultivate the characteristics of the anchor information source to strengthen social sense of presence, empower spatial sense of presence through digital means, and make the sense of presence and customer stickiness work together, so as to boost the modern transformation of enterprises and stimulate consumption potential.